Details of Side Effects when Breast Cancer is Treated with Tamoxifen

TamoxifenTamoxifen is also sold under the brand name: Nolvadex. It is a medicine that is very effective in preventing the recurrence of estrogen-receptor-positive breast cancer. But it does have side effects. I am being treated with Tamoxifen now and some of the side effects cause me issues.

The most serious side-effects of Tamoxifen are blood clots and uterine cancer. Patients who take a commonly prescribed breast cancer drug, Tamoxifen are at an increased risk uterine cancerof developing blood clots. Researchers have discovered that this risk is much greater than without treatment with the drug. The other most serious risk from Tamoxifen is that of developing endometrial cancer. It is about 1 in 500 — a small risk, but higher than that for women in the general population. Tamoxifen also slightly increases the risk of uterine sarcoma, a cancer that begins in the muscle of the uterine wall. Any abnormal vaginal bleeding, bloody vaginal discharge, staining, or spotting should be investigated. Postmenopausal women taking Tamoxifen should be closely monitored for symptoms of endometrial hyperplasia or cancer.

The main side effects of Tamoxifen that I have encountered are, happily, not life-threatening, but are very unpleasant.

The first I noticed was muscle cramps. These are sudden, severe and debilitating. My cramps often affect my legs and feet, but many people complain of cramps in the muscles of their backs too.letrozole-hair

I am also self-conscious of my hair thinning. It has become quite noticable right on the top of my head. I occasionally wear a wig. It disguises my thinning hair and keeps my head warmer!

The third side-effect that causes me problems is that of weight gain. I have not gained a great deal of weight, but neither am I very tall, so any increase in my weight is problematic for me.

Another side-effect that causes me pain and discomfort is joint pain. Often in my knees, this restricts my walking, but also in my fingers and wrists. This curtails my writing and blogging, sometimes.

Last but not least, the side-effect of low mood from Tamoxifen causes problems for me. I suffer from severe clinical depression anyway, but those issues are increased by Tamoxifen and its side-effects.

Still, if taking Tamoxifen keeps the breast cancer at bay, I will continue taking the tablets.

Val Penny

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Breast Cancer – The Side-Effects of Tamoxifen

mammogramI have had breast cancer. After the surgery, the chemotherapy and the radiotherapy, I have spent the last 5 years being treated by the drug letrozole to avoid recurrence of the disease. Last month, I had my annual check-up and mammogram and was found to be 5 years cancer free. Result! However, my tumour was HER2+ and therefore my oncologist has advised another 5 years of endocrine teatment with Tamoxifen.

I suffered from almost every side-effect of Letrozole, so it is important to me to be aware of the side effects I may have to endure while taking Tamoxifen. Everybody reacts differently to drugs and some people experience more severe side effects than others, some are really lucky and are not aware of any side effects.

The most common side effects that people have when taking Tamoxifen are much like Tamoxofen packetthe symptoms of the menopause. They include hot flushes, night sweats and sleep disturbance. Other common side effects are vaginal irritation, loss of sex drive and mood changes. Women who have regular periods are likely to find the flow may be lighter, irregular or stop altogether. However, vaginal discharge is common while taking Tamoxifen and so you should be aware of the possibility of infection,.

One of the positive side effects of Tamoxifen for women who are post-menopausal is that this drug is found to slow down the progress of osteoporosis which is thinning of the bones. Conversely, women sho are pre menopausal may be at risk of thinning bones while taking Tamoxifen.

pulmonary embolismThere are other side effects of Tamoxifen that are less common. The drug increase the risk of getting blood clots including deep vein thrombosis (DVT). This can be very serious as people with DVT are at risk of developing a pulomary embolism. Therefore people taking Tamoxifen need to be aware of blood clots and ways of helping to reduce this. Lengthy periods of inactivity can increase the risk of developing bood clots. Those who take long flights, car journeys or train trips need to be aware of the this.

My oncologist also warned me about the fact that Tamoxifen can afftect the lining of the womb and cause it to thicken. In a few cases Tamoxifen can even cause polyps, ovarian cysts or womb cancer. As my family is complete, I have told the doctors that I would look to have a hysterectomy, should that occur.

letrozole-hairA change in hair may also occur. A small number of women may find they notice an increase in downy facial hair and changes to their singing voice. Others find they suffer hair loss or thinning while taking tamoxifen. I suffered hair loss while taking Letrozole, so will be particularly alert for this side effect.

Sight may also change. Make sure to make your regular visits to your optician during treatment.

Tamoxifen can also cause changes to liver function. However, the changes to the liver are usually mild and you may not notice them. At the end f your Tamoxifen treatment your liver will probably return to normal.

Amongst the other side effects are joint pain, tiredness, difficulty concentrating, letrozole-fluidheadaches and leg cramps at nght. Some women also suffer weight increase.

My oncologist has told me that Tamoxifen usually only results in mild side effects. However, I encountered many of the side effects with Letrozole and fear Tamoxifen may be the same. They cause me distress, pain and make me self conscious. However, if Tamoxifen keeps the dreaded breast cancer at bay, I will take the tablets and live.

Valerie Penny

Breast Cancer Treated With Tamoxifen

I am lucky, I have just been for my annual mammogram and breast cancer check up and I have learned that I am still clear of this horrible disease. It is now 5 years since I wasbreast mammogram diagnosed and treated for breast cancer. 5 years clear: wonderful. However, that does not mean I am treatment free. I have been taking Letrozole for these first five years. The side effects of that drug are many and various. I think I suffered all of them, except high blood pressure! Anyway, the oncologist says it is time to move on from Letrozole to Tamoxifen.

Tamoxifen is another form of hormone treatment, known as endocrine therapy, for those who have had breast cancer. It is only prescribed if the breast cancer had receptors within the cell that bind it to oestrogen. All breast cancers are tested for oestrogen using tissue from a biopsy or after surgery. My tumour was found to be HER2+ and, as this can stimulate cancer tumours to grow, Tamoxifen is prescribed to help stop any cancer cells from growing.

If you are found to be hormone receptor negative, then Tamoxifen will not be of any benefit to you.

Tamoxofen

Primary breast cancer, which has not spread beyond the breast and lymph glands, may be treated with Tamoxifen after surgery. The lymph glands are under your arms. Tamoxifen is used as additional treatment to reduce the risk of the cancer returning and also to reduce the risk of new cancers developing. This is called adjuvant therapy.

Occasionally, Tamoxifen may be used as the first treatment for breast cancer. This may be when surgery is not appropriate or before surgery to shrink a large breast cancer tumour. Shrinking a large tumour in this way may mean that a mastectomy (breast removal) may be avoided and a lumpectomy (removal of the tumour and surrounding tissue) may be sufficient treatment. Also, Tamoxifen may be used for breast cancer that has returned into the breast or surrounding area. It can also be used if you are diagnosed with secondary breast cancer. This is when cancer cells from the breast have spread to other parts of the body.

Tamoxofen packetIn some instances, Tamoxifen may be an option for some people who have a high risk of developing breast cancer because of family history of the disease. This is in order to reduce the risk of development of breast cancer.

 

Tamoxifen is usually taken as a tablet, but may be prescribed as a liquid for those who find swallowing difficult. The recommended dose for the majority of people is 20mg. It is best to take one at the same time each day, but, if you miss a dose, it is not necessary to take an extra tablet because there will be a high enough level of the drug in your body from the previous day.

Usually, you will be prescibed Tamoxifen for a period of between 5 and 10 years. I have been told I should take the drug for a 5 year period. So, here goes, Tamoxifen here I come!

Valerie Penny

 

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